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Bad/In depth Metabolizers, CYP2D6 The development in the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Close to 7% on the population has lessened activity from the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme program. These persons are “poor metabolizers” of debrisoquine, dextromethorphan and tricyclic antide